Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +5.7 ppm indicates the ionisation conditions were gentle enough not to.
aeea_linker
Semaglutide side-chain chemistry and the des-AEEA species.
Section 1
Contribution
Comments technically on records submitted by others. Annotations are signed and are not moderated for agreement.
Records submitted
0
n=0
Annotations
37
n=37
Median purity submitted
suppressed
n=0
n<3 — see individual records
Suppliers covered
0
n=0
This handle has submitted no records. Annotators comment on other people's submissions and are not required to submit.
Section 2
Annotations
Signed technical comments on records. The index does not moderate annotations for agreement with its own arithmetic, and several of these disagree with it. Where a handle has made the same point on several records, one instance is shown and the rest are reachable from the records themselves.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at -1.9 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +1.3 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +0.7 ppm indicates the ionisation conditions were gentle enough not to.
On a side-chain-modified compound the linker is the part most often lost during ionisation, and an in-source fragment can be deconvoluted as the parent. That produces a large negative error rather than a small one.
On side-chain-modified compounds the des-linker species elutes close and carries most of the parent's chromophore. Dual-wavelength detection does not separate them either.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +3.2 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +1.5 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at -1.7 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +0.9 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +0.4 ppm indicates the ionisation conditions were gentle enough not to.
Side-chain-modified compounds lose their linker readily in source, and a clean parent mass at +4.7 ppm indicates the ionisation conditions were gentle enough not to.
Showing 12 distinct comments of 37 annotations by this handle.