AssayIndex

HOMO-2311-R5976

Retatrutide · 5 mg declared · Hunan Aslsen Technology Co., Ltd. · manufactured 17 Nov 2023

CHARACTERISED
Lot code
HOMO-2311-R5976
Supplier
Homopeptide — Hunan Aslsen Technology Co., Ltd.
Compound
Retatrutide
Compound class
Incretin analogues and co-agonists
Declared label claim
5mg
Manufacture date
17 Nov 2023
Index quarter
2024-Q2
Independent assays
11
Laboratories involved
Janoshik, Medutest, PeptideMeter, VendorInvestigate
Provenance mix
Buyer-sourced ×9 · Supplier-supplied ×1 · Laboratory-retained ×1
Section 1

Reproducibility across independent tests

Every report below is an observation of the same physical material. What they disagree about is measurement; what they agree about is the lot. The size of the disagreement is compared against what the contributing laboratories' own repeatability figures predict.

Independent assays 11
Median purity 98.14% n=11
Spread (max − min) 0.90pp n=11
Standard deviation 0.301pp n=11
95.596.397.197.998.799.5100.3This lot (HOMO-2311-R5976)This lot (HOMO-2311-R5976): Q1 97.96, median 98.14, Q3 98.33, n=11n=11All RetatrutideAll Retatrutide: Q1 97.96, median 98.37, Q3 98.82, n=492outlier 95.81outlier 96.13outlier 96.29outlier 96.32outlier 96.46outlier 96.48outlier 96.52outlier 96.54outlier 96.54outlier 96.63outlier 96.64n=492 Purity (% area)
Figure 1. This lot's independent purity results against the whole Retatrutide record set in the index. The vertical line is the index acceptance specification for the incretin analogues and co-agonists class, 96.5 % area. A narrow box on the top row against a wide box on the bottom row is the ideal reading: it means the disagreement between lots is much larger than the disagreement within this one.
Section 2

Member reports 11

Every report the index holds on this lot. Each is a page carrying its own chromatogram, mass spectrum, mass balance, provenance and caveats.

ReportLotLabQuarterPurity %Water %Recovery %ProvenanceFlagsResult
AX-2024-004774HOMO-2311-R5976Janoshik2024-Q298.623.11Buyer-sourced0PASS
AX-2024-004775HOMO-2311-R5976Medutest2024-Q297.822.09Buyer-sourced1FAIL
AX-2024-004776HOMO-2311-R5976PeptideMeter2024-Q298.173.48Buyer-sourced0PASS
AX-2024-004777HOMO-2311-R5976Medutest2024-Q297.983.3897.0Buyer-sourced1MARGINAL
AX-2024-004778HOMO-2311-R5976Janoshik2024-Q298.222.99Laboratory-retained0PASS
AX-2024-004779HOMO-2311-R5976VendorInvestigate2024-Q298.443.02Buyer-sourced0PASS
AX-2024-004780HOMO-2311-R5976Janoshik2024-Q298.722.58Supplier-supplied0PASS
AX-2024-004781HOMO-2311-R5976Janoshik2024-Q298.143.27Buyer-sourced0PASS
AX-2024-004782HOMO-2311-R5976Janoshik2024-Q297.863.3689.2Buyer-sourced1MARGINAL
AX-2024-004783HOMO-2311-R5976Janoshik2024-Q298.053.5594.8Buyer-sourced0PASS
AX-2024-004784HOMO-2311-R5976Medutest2024-Q297.933.67Buyer-sourced0PASS
Section 3

By laboratory

Where more than one laboratory assayed this lot, the difference between them is a paired observation of their relative bias — the same material, the same time window, different instruments. Those pairs are what the index's bias estimates are built from.

LaboratoryReportsPurity results (% area)MedianGradientPublished bias (pp)Bias-adjusted
Janoshik698.62, 98.22, 98.72, 98.14, 97.86, 98.0598.1830min+0.0098.18
Medutest397.82, 97.98, 97.9397.9325min+0.0897.85
PeptideMeter198.1798.1728min-0.0598.22
VendorInvestigate198.4498.4432min-0.1198.55

This lot contributes 6 paired comparisons to the inter-lab analysis.

Section 4

The supplier's certificate for this lot

One number the supplier wrote, beside the median of the numbers other people measured on the same physical material. That comparison is only available because the index groups by lot.

FigureSupplier COAThis reportIndex note
Purity (% area)98.3798.62divergence +0.23 pp vs batch median
Total impurities (% area)not stated1.38
Largest single impurity (% area)not stated0.69
Water (%)1.73.11
Counter-ion (%)2.69.46
Peptide content (%w/w)95.1not determined
Endotoxin (EU/mg)not statednot determined
Method stated on certificateYEScolumn, gradient and wavelength given
Section 5

Impurity fingerprint

The named impurities reported across this lot's assays, with how consistently each was seen. A fingerprint is what allows two lot numbers held by different companies to be identified as one bulk.

Named impurityReported inMedian % areaRange
C18 diacid regioisomer11 / 110.640.08–1.06
truncated (5-39)11 / 110.290.04–0.49
des-Aib20 analogue11 / 110.360.21–0.56
retatrutide dimer11 / 110.100.06–1.17
aspartimide (−18 Da)11 / 110.050.04–0.08
[D-Aib2]-diastereomer11 / 110.050.03–0.23
Section 7

What this rollup does not establish