Cross-section

5-Amino-1MQ by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for 5-Amino-1MQ, with a class minimum gradient of 15 min, the method is a live explanation.

78 recordsmedian 99.45 %spec 98.0 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	36	30min	High	99.49	+0.00	99.49	ADEQUATE
PeptideMeter	13	28min	High	99.52	-0.05	99.57	ADEQUATE
Medutest	13	25min	Unit	99.57	+0.08	99.49	ADEQUATE
VendorInvestigate	8	32min	High	98.92	-0.11	99.03	ADEQUATE
Kestrel	6 n=6	15min	Unit	99.70	+0.24	99.47	ADEQUATE
Nordanalyt	2 n=2	35min	High	99.46, 99.34	+0.02	—	ADEQUATE

Figure. 5-Amino-1MQ purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.