GHRP-6 impurity profile
Every named species the index has reported alongside GHRP-6, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.46%
n=206
Median largest single
0.25%
n=206
Worst single observed
1.11%
n=206
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| [D-Trp]-epimer | -0.12 | mass-identical | 93% | 0.08 | 0.95 |
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 91% | 0.13 | 0.89 |
| des-Lys (−128 Da) | -0.22 | -128.095 | 88% | 0.06 | 1.11 |
| bis-oxidised Trp (+32 Da) | -0.58 | +31.990 | 84% | 0.07 | 1.03 |
[D-Trp]-epimer
- Retention offset from the main peak
- -0.12 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 192 of 206 records (93 %)
- Level when reported
- median 0.08 %, max 0.95 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 187 of 206 records (91 %)
- Level when reported
- median 0.13 %, max 0.89 %
- How it separates
- Baseline-resolved on the reference method.
des-Lys (−128 Da)
- Retention offset from the main peak
- -0.22 min on RG-2
- Mass difference
- -128.095 Da
- Reported in
- 181 of 206 records (88 %)
- Level when reported
- median 0.06 %, max 1.11 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
bis-oxidised Trp (+32 Da)
- Retention offset from the main peak
- -0.58 min on RG-2
- Mass difference
- +31.990 Da
- Reported in
- 174 of 206 records (84 %)
- Level when reported
- median 0.07 %, max 1.03 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- double Trp oxidation — GHRP-6 has two, and both go
- C-terminal amide hydrolysis