IGF-1 DES (1-3) impurity profile
Every named species the index has reported alongside IGF-1 DES (1-3), how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.88%
n=15
Median largest single
0.55%
n=15
Worst single observed
1.19%
n=15
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| full-length IGF-1 (+343 Da) | +0.48 | +342.166 | 100% | 0.09 | 0.89 |
| disulfide-scrambled isomer | +0.58 | mass-identical | 100% | 0.24 | 0.80 |
| des(1-4) over-truncate (−87 Da) | -0.36 | -87.032 | 100% | 0.32 | 1.19 |
| aggregated dimer | +3.05 | +7365.719 | 100% | 0.05 | 0.31 |
full-length IGF-1 (+343 Da)
- Retention offset from the main peak
- +0.48 min on RG-2
- Mass difference
- +342.166 Da
- Reported in
- 15 of 15 records (100 %)
- Level when reported
- median 0.09 %, max 0.89 %
- How it separates
- Baseline-resolved on the reference method.
disulfide-scrambled isomer
- Retention offset from the main peak
- +0.58 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 15 of 15 records (100 %)
- Level when reported
- median 0.24 %, max 0.80 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
des(1-4) over-truncate (−87 Da)
- Retention offset from the main peak
- -0.36 min on RG-2
- Mass difference
- -87.032 Da
- Reported in
- 15 of 15 records (100 %)
- Level when reported
- median 0.32 %, max 1.19 %
- How it separates
- Baseline-resolved on the reference method.
aggregated dimer
- Retention offset from the main peak
- +3.05 min on RG-2
- Mass difference
- +7365.719 Da
- Reported in
- 15 of 15 records (100 %)
- Level when reported
- median 0.05 %, max 0.31 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- disulfide scrambling
- over-digestion to des(1-4) during production