AssayIndex
Cross-section

Leuprolide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Leuprolide, with a class minimum gradient of 15 min, the method is a live explanation.

29 recordsmedian 99.28 %spec 98.5 %
LaboratoryReportsGradientMS resolutionMedian purity %Published bias (pp)Bias-adjustedMethod suitability
Janoshik1330minHigh99.32+0.0099.32ADEQUATE
Medutest5 n=525minUnit99.59+0.0899.51ADEQUATE
PeptideMeter4 n=428minHigh99.18-0.0599.23ADEQUATE
VendorInvestigate4 n=432minHigh98.97-0.1199.08ADEQUATE
Nordanalyt2 n=235minHigh99.83, 99.41+0.02—ADEQUATE
Kestrel1 n=115minUnit98.48+0.24—ADEQUATE
98.598.799.099.399.599.8100.0JanoshikJanoshik: Q1 99.11, median 99.32, Q3 99.53, n=13n=13PeptideMeterPeptideMeter: Q1 99.03, median 99.18, Q3 99.28, n=4outlier 98.63n=4MedutestMedutest: Q1 99.11, median 99.59, Q3 99.61, n=5n=5VendorInvestigateVendorInvestigate: Q1 98.71, median 98.97, Q3 99.32, n=4n=4NordanalytNordanalyt: Q1 99.52, median 99.62, Q3 99.72, n=2n=2 Purity (% area)
Figure. Leuprolide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.