Thymosin α1 impurity profile
Every named species the index has reported alongside Thymosin α1, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.60%
n=43
Median largest single
0.36%
n=43
Worst single observed
1.20%
n=43
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| deamidated Asn (+1 Da) | -0.34 | +0.984 | 100% | 0.09 | 1.17 |
| des-acetyl Tα1 (−42 Da) | -0.68 | -42.011 | 98% | 0.17 | 1.20 |
| truncated (1-24) | -1.24 | -487.229 | 93% | 0.06 | 0.49 |
| aspartimide (−18 Da) | +0.42 | -18.011 | 84% | 0.10 | 0.97 |
deamidated Asn (+1 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 43 of 43 records (100 %)
- Level when reported
- median 0.09 %, max 1.17 %
- How it separates
- Baseline-resolved on the reference method.
des-acetyl Tα1 (−42 Da)
- Retention offset from the main peak
- -0.68 min on RG-2
- Mass difference
- -42.011 Da
- Reported in
- 42 of 43 records (98 %)
- Level when reported
- median 0.17 %, max 1.20 %
- How it separates
- Baseline-resolved on the reference method.
truncated (1-24)
- Retention offset from the main peak
- -1.24 min on RG-2
- Mass difference
- -487.229 Da
- Reported in
- 40 of 43 records (93 %)
- Level when reported
- median 0.06 %, max 0.49 %
- How it separates
- Baseline-resolved on the reference method.
aspartimide (−18 Da)
- Retention offset from the main peak
- +0.42 min on RG-2
- Mass difference
- -18.011 Da
- Reported in
- 36 of 43 records (84 %)
- Level when reported
- median 0.10 %, max 0.97 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- N-terminal acetyl loss
- Asn deamidation
- aspartimide at Asp-Gly