MK-677 (Ibutamoren mesylate) impurity profile
Every named species the index has reported alongside MK-677 (Ibutamoren mesylate), how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.51%
n=143
Median largest single
0.25%
n=143
Worst single observed
1.14%
n=143
Named species observed
5 / 5
n=5
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| free base (des-mesylate, −96 Da) | +0.04 | -96.011 | 91% | 0.07 | 0.87 |
| spiroindane regioisomer | +0.44 | mass-identical | 85% | 0.07 | 1.02 |
| sulfonamide hydrolysis product (+18 Da) | -0.86 | +18.011 | 76% | 0.16 | 1.14 |
| O-desmethyl metabolite analogue (−14 Da) | -0.52 | -14.016 | 73% | 0.05 | 0.91 |
| residual DMF (process solvent) | -8.20 | -551.000 | 69% | 0.06 | 0.57 |
free base (des-mesylate, −96 Da)
- Retention offset from the main peak
- +0.04 min on RG-2
- Mass difference
- -96.011 Da
- Reported in
- 130 of 143 records (91 %)
- Level when reported
- median 0.07 %, max 0.87 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
spiroindane regioisomer
- Retention offset from the main peak
- +0.44 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 121 of 143 records (85 %)
- Level when reported
- median 0.07 %, max 1.02 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
sulfonamide hydrolysis product (+18 Da)
- Retention offset from the main peak
- -0.86 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 108 of 143 records (76 %)
- Level when reported
- median 0.16 %, max 1.14 %
- How it separates
- Baseline-resolved on the reference method.
O-desmethyl metabolite analogue (−14 Da)
- Retention offset from the main peak
- -0.52 min on RG-2
- Mass difference
- -14.016 Da
- Reported in
- 105 of 143 records (73 %)
- Level when reported
- median 0.05 %, max 0.91 %
- How it separates
- Baseline-resolved on the reference method.
residual DMF (process solvent)
- Retention offset from the main peak
- -8.20 min on RG-2
- Mass difference
- -551.000 Da
- Reported in
- 99 of 143 records (69 %)
- Level when reported
- median 0.06 %, max 0.57 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- sulfonamide hydrolysis under strongly basic conditions
- no oxidative or proteolytic liability