SS-31 (Elamipretide) impurity profile
Every named species the index has reported alongside SS-31 (Elamipretide), how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.46%
n=124
Median largest single
0.27%
n=124
Worst single observed
1.59%
n=124
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| [D-Arg1]-epimer | -0.18 | mass-identical | 93% | 0.11 | 1.27 |
| acetyl adduct (+42 Da) | +0.54 | +42.011 | 89% | 0.10 | 1.59 |
| des-Dmt (−193 Da) | -0.72 | -193.110 | 87% | 0.10 | 0.58 |
| C-terminal free acid (+1 Da) | +0.20 | +0.984 | 85% | 0.12 | 1.07 |
[D-Arg1]-epimer
- Retention offset from the main peak
- -0.18 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 115 of 124 records (93 %)
- Level when reported
- median 0.11 %, max 1.27 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
acetyl adduct (+42 Da)
- Retention offset from the main peak
- +0.54 min on RG-2
- Mass difference
- +42.011 Da
- Reported in
- 110 of 124 records (89 %)
- Level when reported
- median 0.10 %, max 1.59 %
- How it separates
- Baseline-resolved on the reference method.
des-Dmt (−193 Da)
- Retention offset from the main peak
- -0.72 min on RG-2
- Mass difference
- -193.110 Da
- Reported in
- 108 of 124 records (87 %)
- Level when reported
- median 0.10 %, max 0.58 %
- How it separates
- Baseline-resolved on the reference method.
C-terminal free acid (+1 Da)
- Retention offset from the main peak
- +0.20 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 106 of 124 records (85 %)
- Level when reported
- median 0.12 %, max 1.07 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- C-terminal amide hydrolysis
- epimerisation at Arg1 under prolonged basic coupling